Research for infection protection
  • germs
  • Adenovirus
  • Aspergillus niger
  • Bovine virus diarrhea
  • Clostridium difficile
  • Candida albicans
  • Candida albicans
  • Coronavirus
  • Corynebacterium
  • Escherichia coli
  • Helicobacter pylori

Author: Kampf G et al. (2002) Source: J Hosp Infect. 2002 Oct; 52 (2):141-7.


Kampf G et al. (2002)

Spectrum of antimicrobial activity and user acceptability of the hand disinfectant agent Sterillium® Gel

Background: Healthcare workers are advised not to use alcohol-based gels for hand disinfection, as they only contain low alcohol concentrations and often are less effective against microorganisms than liquid hand disinfectants. The study investigated the antimicrobial efficacy and user acceptance of Sterillium® Gel, a hand gel with 85 % ethanol.

Methods: Bactericidal activity was tested in accordance with prEN 12054 and under practical conditions in accordance with EN 1500 (15 test persons and four replicates). In addition, the product’s fungicidal, tuberculocidal and virucidal activity was examined. User acceptance was evaluated in four hospitals in France and the UK: 96 employees used the gel for hygienic hand disinfection for four weeks and afterwards assessed by anwering a questionnaire.

Results: The product proved to be bactericidal (log10 reduction factor > 5), tuberculocidal (log10 RF > 5) and fungicidal (log10 RF > 4) within 30 seconds. Independent of the organic load, the gel reduced relevant virus types by > 4 log10 steps, for example, adenovirus (2 minutes), poliovirus (3 minutes), as well as rotavirus and HIV (30 seconds). In four independent tests, Sterillium® Gel met the EN 1500 efficacy requirements (3 ml within 30 seconds). Under practical use conditions, the preparation was as effective within 30 seconds as the reference procedure within 60 seconds. The majority of users rated, for example, the viscosity, skin feel after use and smell as positive or acceptable. Overall, 65.6 % of the test users assessed the new gel as better than the gel or liquid product they used before.

Conclusions: The analysed product proved to have an extremely broad spectrum of antimicrobial activity. Hence, it is suitable for use for hygienic hand disinfection in the clinical setting. It is the first hand gel reproducibly fulfilling the EN 1500 requirements with 3 ml within 30 seconds. The gel achieved high user acceptance and thus offers favourable conditions for high compliance with hand hygiene protocols.

J Hosp Infect. 2002 Oct; 52 (2):141-7.

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