Research for infection protection
  • germs
  • Adenovirus
  • Aspergillus niger
  • Bovine virus diarrhea
  • Clostridium difficile
  • Candida albicans
  • Candida albicans
  • Coronavirus
  • Corynebacterium
  • Escherichia coli
  • Helicobacter pylori

Author: Barry (2014) Source: RCTS’ Study No. 3295


Barry (2014)

Evaluating the effect of a hand sanitiser using an exaggerated handwash method

Background: To improve the compliance in hand hygiene and to effectively prevent infections, hand disinfectants need to be effective and accepted by the users. In terms of efficacy and skin tolerability, alcohol-based hand disinfectants are considered the state of the art in hand hygiene. However, there are often concerns that frequent hand disinfection with alcohol-based products might dry the skin or disturb the skin barrier. Hence, besides possessing a reliable efficacy, hand disinfectants need to be skin friendly or even exhibit skin caring effects e.g. by moisturizing the skin.

The prospective clinical study examined the effects of Sterillium classic pure on skin of 29 healthy subjects with special emphasis concerning skin caring effects. The intention was to simulate intensive hygienic hand disinfection similar to daily clinical routine. Three ml of Sterillium classic pure were applied to the designated hand of the subject and rubbed in for 30 seconds by a technician using gloved hands and allowed to air dry for at least 40 seconds. This procedure was repeated 30 times per day during 10 treatment Days. Thus, Sterillium classic pure was applied 300 times to every subject. The second hand was not treated and served as control.
Duration of the study was 12 Days. Skin moisture, skin elasticity, skin pH, skin elasticity, desquamation index, skin texture and wrinkles, and transepidermal water loss (TEWL) were measured. The objective assessment of the skin tolerability included dryness and inflammatory skin changes by a clinical grader. The subjective skin tolerability was defined on the basis of dryness values, and the assessment of redness, and the overall condition and the feel of tension in the skin by the subjects.

Results: The increased corneometer values showed that the intensive application of Sterillium classic pure resulted in a significantly improved skin hydration on every measuring time point compared to baseline and compared to the untreated hand. At the end of the first test week, skin hydration had significantly increased by 30.39%. On the tenth day, the increase in skin hydration was 39.33%. The subjective perception reflected these results: at all time points, the skin dryness declined compared to the baseline (pre-value).

Conclusions: The repeated daily use of Sterillium classic pure significantly increases corneometer values, indicating an increase in skin hydration. This result was further substantiated by skin firmness data, desquamation index and subjects self-assessment of dryness. Furthermore, measurement of transepidermal water loss suggests that the skin barrier remains within the range of healthy skin. The same holds true for the measured pH-values which also remained within the range of healthy skin.

As the formulations of Sterillium and Sterillium classic pure are identical except colourants and fragrance, the skin caring properties of both products are comparable.

RCTS’ Study No. 3295

Click here to read the article “Basis for good hand hygiene compliance: skincare substances and role models”.