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Author: Reichel M et al. (2014) Source: BMC Infect Dis. 2014 May 28; 14(1):292

STUDY

Reichel M et al. (2014)

Efficacy of surface disinfectant cleaners against emerging highly resistant gram-negative bacteria

Background: The emergence of multidrug-resistant gram-negative bacteria is a clinical problem worldwide. Surface disinfectant cleaners that are effective against these bacteria are needed for use in high risk areas around patients and on multi-touch surfaces. In the present study, the efficacy of five surface disinfectant cleaners against clinically relevant multidrug-resistant gram-negative bacteria was determined.


Methods: Antibiotic-susceptible clinical isolates, multi-resistant clinical isolates and/or laboratory strains (ATCC) of the following species were used: Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Serratia marcescens, Achromobacter xylosoxidans and Klebsiella oxytoca. The five evaluated surface disinfectant cleaners were based on alcohol and an amphoteric substance (AAS), an oxygen-releaser (OR), surface-active substances (SAS), or surface active-substances plus aldehydes (SASA; two formulations). The efficacy of the surface disinfectant cleaners was determined according to EN 13727:2012 in quadruplicate under dirty conditions at two different contact times. A product was regarded effective if it achieved a log10-reduction in bacterial cell count of ≥ 5.


Results: The results show that the tested surface disinfectant cleaners based on AAS, OR, and SAS are effective against all six species (log10-reduction ≥ 5) irrespective of the degree of multi-resistance. The SASA formulations are also effective against the bacteria except for one of the four tested P. aeruginosa isolates (VIM-1). No general correlation was found between surface disinfectant cleaners’ efficacy and degree of antibiotic resistance.


Conclusion: The tested surface disinfectant cleaners are generally effective against gram-negative bacteria with and without multidrug resistance. The surface disinfectant cleaners are therefore suitable for surface disinfection in the immediate proximity of patients. However, single bacterial isolates might have reduced susceptibility to selected biocidal agents.


Source:
BMC Infect Dis. 2014 May 28; 14(1):292


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